PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis.

ABSTRACT: We have cloned a lytic enzyme, PlyPH, with a specific lytic effect on Bacillus anthracis strains. PlyPH remains active between pH 4 and 10.5, and a single dose rescued a significant percentage of mice infected intraperitoneally with an attenuated B. anthracis strain. We propose PlyPH as a novel therapeutic agent.

SUBMITTER: Yoong P 

PROVIDER: S-EPMC1428399 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature