Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases.

ABSTRACT:

Background

Methionine sulfoxide reduction is an important protein repair pathway that protects against oxidative stress, controls protein function and has a role in regulation of aging. There are two enzymes that reduce stereospecifically oxidized methionine residues: MsrA (methionine-S-sulfoxide reductase) and MsrB (methionine-R-sulfoxide reductase). In many organisms, these enzymes are targeted to various cellular compartments. In mammals, a single MsrA gene is known, however, its product is present in cytosol, nucleus, and mitochondria. In contrast, three mammalian MsrB genes have been identified whose products are located in different cellular compartments.

Results

In the present study, we identified and characterized alternatively spliced forms of mammalian MsrA. In add

SUBMITTER: Kim HY 

PROVIDER: S-EPMC1431549 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature