Identification of signaling components required for the prediction of cytokine release in RAW 264.7 macrophages.

ABSTRACT:

Background

Release of immuno-regulatory cytokines and chemokines during inflammatory response is mediated by a complex signaling network. Multiple stimuli produce different signals that generate different cytokine responses. Current knowledge does not provide a complete picture of these signaling pathways. However, using specific markers of signaling pathways, such as signaling proteins, it is possible to develop a 'coarse-grained network' map that can help understand common regulatory modules for various cytokine responses and help differentiate between the causes of their release.

Results

Using a systematic profiling of signaling responses and cytokine release in RAW 264.7 macrophages made available by the Alliance for Cellular Signaling, an analysis strategy is presented

SUBMITTER: Pradervand S 

PROVIDER: S-EPMC1431720 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature