Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites.

ABSTRACT:

Background

The apicomplexan parasite Plasmodium falciparum causes the most severe form of malaria in humans. After invasion into erythrocytes, asexual parasite stages drastically alter their host cell and export remodeling and virulence proteins. Previously, we have reported identification and functional analysis of a short motif necessary for export of proteins out of the parasite and into the red blood cell.

Results

We have developed software for the prediction of exported proteins in the genus Plasmodium, and identified exported proteins conserved between malaria parasites infecting rodents and the two major causes of human malaria, P. falciparum and P. vivax. This conserved 'exportome' is confined to a few subtelomeric chromosomal regions in P. falciparum and the synteny

SUBMITTER: Sargeant TJ 

PROVIDER: S-EPMC1431722 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature