Lung fibroblasts from patients with emphysema show markers of senescence in vitro.

ABSTRACT:

Background

The loss of alveolar walls is a hallmark of emphysema. As fibroblasts play an important role in the maintenance of alveolar structure, a change in fibroblast phenotype could be involved in the pathogenesis of this disease. In a previous study we found a reduced in vitro proliferation rate and number of population doublings of parenchymal lung fibroblasts from patients with emphysema and we hypothesized that these findings could be related to a premature cellular aging of these cells. In this study, we therefore compared cellular senescence markers and expression of respective genes between lung fibroblasts from patients with emphysema and control patients without COPD.

Methods

Primary lung fibroblasts were obtained from 13 patients with moderate to severe lung emp

SUBMITTER: Muller KC 

PROVIDER: S-EPMC1435750 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature