Methodological quality of systematic reviews of animal studies: a survey of reviews of basic research.

ABSTRACT:

Background

Systematic reviews can serve as a tool in translation of basic life sciences research from laboratory to human research and healthcare. The extent to which reviews of animal research are systematic and unbiased is not known.

Methods

We searched, without language restrictions, Medline, Embase, bibliographies of known reviews (1996-2004) and contacted experts to identify citations of reviews of basic science literature which, as a minimum, performed search of a publicly available resource. From these we identified reviews of animal studies where laboratory variables were measured or where treatments were administered to live animals to examine their effects, and compared them with reviews of bench studies in which human or animal tissues, cell systems or organ prepa

SUBMITTER: Mignini LE 

PROVIDER: S-EPMC1435907 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature