Multiple lineage specific expansions within the guanylyl cyclase gene family.

ABSTRACT:

Background

Guanylyl cyclases (GCs) are responsible for the production of the secondary messenger cyclic guanosine monophosphate, which plays important roles in a variety of physiological responses such as vision, olfaction, muscle contraction, homeostatic regulation, cardiovascular and nervous function. There are two types of GCs in animals, soluble (sGCs) which are found ubiquitously in cell cytoplasm, and receptor (rGC) forms which span cell membranes. The complete genomes of several vertebrate and invertebrate species are now available. These data provide a platform to investigate the evolution of GCs across a diverse range of animal phyla.

Results

In this analysis we located GC genes from a broad spectrum of vertebrate and invertebrate animals and reconstructed molecular

SUBMITTER: Fitzpatrick DA 

PROVIDER: S-EPMC1435932 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature