An improved map of conserved regulatory sites for Saccharomyces cerevisiae.

ABSTRACT:

Background

The regulatory map of a genome consists of the binding sites for proteins that determine the transcription of nearby genes. An initial regulatory map for S. cerevisiae was recently published using six motif discovery programs to analyze genome-wide chromatin immunoprecipitation data for 203 transcription factors. The programs were used to identify sequence motifs that were likely to correspond to the DNA-binding specificity of the immunoprecipitated proteins. We report improved versions of two conservation-based motif discovery algorithms, PhyloCon and Converge. Using these programs, we create a refined regulatory map for S. cerevisiae by reanalyzing the same chromatin immunoprecipitation data.

Results

Applying the same conservative criteria that were applied in t

SUBMITTER: MacIsaac KD 

PROVIDER: S-EPMC1435934 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature