Ensemble attribute profile clustering: discovering and characterizing groups of genes with similar patterns of biological features.

ABSTRACT:

Background

Ensemble attribute profile clustering is a novel, text-based strategy for analyzing a user-defined list of genes and/or proteins. The strategy exploits annotation data present in gene-centered corpora and utilizes ideas from statistical information retrieval to discover and characterize properties shared by subsets of the list. The practical utility of this method is demonstrated by employing it in a retrospective study of two non-overlapping sets of genes defined by a published investigation as markers for normal human breast luminal epithelial cells and myoepithelial cells.

Results

Each genetic locus was characterized using a finite set of biological properties and represented as a vector of features indicating attributes associated with the locus (a gene attrib

SUBMITTER: Semeiks JR 

PROVIDER: S-EPMC1435935 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature