Ontology highlight
ABSTRACT:
SUBMITTER: Nielsen JT
PROVIDER: S-EPMC1435981 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Nielsen Jakob T JT Arar Khalil K Petersen Michael M
Nucleic acids research 20060413 7
We have determined the NMR solution structures of the quadruplexes formed by d(TGLGLT) and d(TL4T), where L denotes LNA (locked nucleic acid) modified G-residues. Both structures are tetrameric, parallel and right-handed and the native global fold of the corresponding DNA quadruplex is retained upon introduction of the LNA nucleotides. However, local structural alterations are observed owing to the locked LNA sugars. In particular, a distinct change in the sugar-phosphate backbone is observed at ...[more]