NovelFam3000--uncharacterized human protein domains conserved across model organisms.

ABSTRACT:

Background

Despite significant efforts from the research community, an extensive portion of the proteins encoded by human genes lack an assigned cellular function. Most metazoan proteins are composed of structural and/or functional domains, of which many appear in multiple proteins. Once a domain is characterized in one protein, the presence of a similar sequence in an uncharacterized protein serves as a basis for inference of function. Thus knowledge of a domain's function, or the protein within which it arises, can facilitate the analysis of an entire set of proteins.

Description

From the Pfam domain database, we extracted uncharacterized protein domains represented in proteins from humans, worms, and flies. A data centre was created to facilitate the analysis of the uncha

SUBMITTER: Kemmer D 

PROVIDER: S-EPMC1440326 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature