A nonparametric test reveals selection for rapid flowering in the Arabidopsis genome.

ABSTRACT: The detection of footprints of natural selection in genetic polymorphism data is fundamental to understanding the genetic basis of adaptation, and has important implications for human health. The standard approach has been to reject neutrality in favor of selection if the pattern of variation at a candidate locus was significantly different from the predictions of the standard neutral model. The problem is that the standard neutral model assumes more than just neutrality, and it is almost always possible to explain the data using an alternative neutral model with more complex demography. Today's wealth of genomic polymorphism data, however, makes it possible to dispense with models altogether by simply comparing the pattern observed at a candidate locus to the genomic pattern, and rejectin

SUBMITTER: Toomajian C 

PROVIDER: S-EPMC1440937 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature