Identification of zebrafish insertional mutants with defects in visual system development and function.

ABSTRACT: Genetic analysis in zebrafish has been instrumental in identifying genes necessary for visual system development and function. Recently, a large-scale retroviral insertional mutagenesis screen, in which 315 different genes were mutated, that resulted in obvious phenotypic defects by 5 days postfertilization was completed. That the disrupted gene has been identified in each of these mutants provides unique resource through which the formation, function, or physiology of individual organ systems can be studied. To that end, a screen for visual system mutants was performed on 250 of the mutants in this collection, examining each of them histologically for morphological defects in the eye and behaviorally for overall visual system function. Forty loci whose disruption resulted in defects in ey

SUBMITTER: Gross JM 

PROVIDER: S-EPMC1444939 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature