The Mcp element mediates stable long-range chromosome-chromosome interactions in Drosophila.

ABSTRACT: Chromosome organization inside the nucleus is not random but rather is determined by a variety of factors, including interactions between chromosomes and nuclear components such as the nuclear envelope or nuclear matrix. Such interactions may be critical for proper nuclear organization, chromosome partitioning during cell division, and gene regulation. An important, but poorly documented subset, includes interactions between specific chromosomal regions. Interactions of this type are thought to be involved in long-range promoter regulation by distant enhancers or locus control regions and may underlie phenomena such as transvection. Here, we used an in vivo microscopy assay based on Lac Repressor/operator recognition to show that Mcp, a polycomb response element from the Drosophila bithora

SUBMITTER: Vazquez J 

PROVIDER: S-EPMC1446072 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature