POLKADOTS are foci of functional interactions in T-Cell receptor-mediated signaling to NF-kappaB.

ABSTRACT: Stimulation of the T-cell receptor (TCR) results in the activation of several transcription factors, including NF-kappaB, that are crucial for T-cell proliferation and gain of effector functions. On TCR engagement, several proteins within the TCR-directed NF-kappaB signaling pathway undergo dynamic spatial redistribution, but the significance of these redistribution events is largely unknown. We have previously described TCR-induced cytoplasmic structures called POLKADOTS (punctate and oligomeric killing or activating domains transducing signals) that are enriched in the NF-kappaB signaling intermediate, Bcl10. We now show that these structures are formed only under conditions that promote efficient NF-kappaB activation. Furthermore, POLKADOTS formation is dependent on functional domains o

SUBMITTER: Rossman JS 

PROVIDER: S-EPMC1446088 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature