Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes.

ABSTRACT: Using an unsupervised pattern-discovery method, we processed the human intergenic and intronic regions and catalogued all variable-length patterns with identically conserved copies and multiplicities above what is expected by chance. Among the millions of discovered patterns, we found a subset of 127,998 patterns, termed pyknons, which have additional nonoverlapping instances in the untranslated and protein-coding regions of 30,675 transcripts from 20,059 human genes. The pyknons arrange combinatorially in the untranslated and coding regions of numerous human genes where they form mosaics. Consecutive instances of pyknons in these regions show a strong bias in their relative placement, favoring distances of approximately 22 nucleotides. We also found pyknons to be enriched in a statistical

SUBMITTER: Rigoutsos I 

PROVIDER: S-EPMC1447521 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature