A novel magnetic resonance-based method to measure gene expression in living cells.

ABSTRACT: In unicellular and multicellular eukaryotes, elaborate gene regulatory mechanisms facilitate a broad range of biological processes from cell division to morphological differentiation. In order to fully understand the gene regulatory networks involved in these biological processes, the spatial and temporal patterns of expression of many thousands of genes will need to be determined in real time in living organisms. Currently available techniques are not sufficient to achieve this goal; however, novel methods based on magnetic resonance (MR) imaging may be particularly useful for sensitive detection of gene expression in opaque tissues. This report describes a novel reporter gene system that monitors gene expression dynamically and quantitatively, in yeast cells, by measuring the accumulatio

SUBMITTER: Ki S 

PROVIDER: S-EPMC1447650 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature