Identification of a locus under complex positive selection in Drosophila simulans by haplotype mapping and composite-likelihood estimation.

ABSTRACT: The recent action of positive selection is expected to influence patterns of intraspecific DNA sequence variation in chromosomal regions linked to the selected locus. These effects include decreased polymorphism, increased linkage disequilibrium, and an increased frequency of derived variants. These effects are all expected to dissipate with distance from the selected locus due to recombination. Therefore, in regions of high recombination, it should be possible to localize a target of selection to a relatively small interval. Previously described patterns of intraspecific variation in three tandemly arranged, testes-expressed genes (janusA, janusB, and ocnus) in Drosophila simulans included all three of these features. Here we expand the original sample and also survey nucleotide polymorph

SUBMITTER: Meiklejohn CD 

PROVIDER: S-EPMC1448127 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature