Periodicity of SNP distribution around transcription start sites.

ABSTRACT:

Background

Several millions single nucleotide polymorphisms (SNPs) have already been collected and deposited in public databases and these are important resources not only for use as markers to identify disease-associated genes, but also to understand the mechanisms that underlie the genome diversification.

Results

A spectrum analysis of SNP density distribution in the genomic regions around transcription start sites (TSSs) revealed a remarkable periodicity of 146 nucleotides. This periodicity was observed in the regions that were associated with CpG islands (CGIs), but not in the regions without CpG islands (nonCGIs). An analysis of the sequence divergence of the same genomic regions between humans and chimpanzees also revealed a similar periodical pattern in CGI. The occur

SUBMITTER: Higasa K 

PROVIDER: S-EPMC1448210 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature