The phosphopantetheinyl transferase superfamily: phylogenetic analysis and functional implications in cyanobacteria.

ABSTRACT: Phosphopantetheinyl transferases (PPTs) are a superfamily of essential enzymes required for the synthesis of a wide range of compounds including fatty acid, polyketide, and nonribosomal peptide metabolites. These enzymes activate carrier proteins in specific biosynthetic pathways by the transfer of a phosphopantetheinyl moiety to an invariant serine residue. PPTs display low levels of sequence similarity but can be classified into two major families based on several short motifs. The prototype of the first family is the broad-substrate-range PPT Sfp, which is required for biosynthesis of surfactin in Bacillus subtilis. The second family is typified by the Escherichia coli acyl carrier protein synthase (AcpS). Facilitated by the growing number of genome sequences available for analyses, lar

SUBMITTER: Copp JN 

PROVIDER: S-EPMC1449050 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature