Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans.

ABSTRACT: Scavenger receptor proteins are involved in the cellular internalization of a broad variety of foreign material, including pathogenic bacteria during phagocytosis. I find here that nonsynonymous divergence in three class C scavenger receptors (Sr-C's) between Drosophila melanogaster and D. simulans and between each of these species and D. yakuba is approximately four times the typical genome average. These genes also exhibit unusually high levels of segregating nonsynonymous polymorphism in D. melanogaster and D. simulans populations. A fourth Sr-C is comparatively conserved. McDonald-Kreitman tests reveal a significant excess of replacement fixations between D. melanogaster and D. simulans in the Sr-C's, but tests of polymorphic site frequency spectra do not support models of directional

SUBMITTER: Lazzaro BP 

PROVIDER: S-EPMC1449580 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature