Differential activation of M26-containing meiotic recombination hot spots in Schizosaccharomyces pombe.

ABSTRACT: Certain genomic loci, termed hot spots, are predisposed to undergo genetic recombination during meiosis at higher levels relative to the rest of the genome. The factors that specify hot-spot potential are not well understood. The M26 hot spot of Schizosaccharomyces pombe is dependent on certain trans activators and a specific nucleotide sequence, which can function as a hot spot in a position- and orientation-independent fashion within ade6. In this report we demonstrate that a linear element (LE) component, Rec10, has a function that is required for activation of some, but not all, M26-containing hot spots and from this we propose that, with respect to hot-spot activity, there are three classes of M26-containing sequences. We demonstrate that the localized sequence context in which the M2

SUBMITTER: Pryce DW 

PROVIDER: S-EPMC1449712 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature