Genetic polymorphisms in arginase I and II and childhood asthma and atopy.

ABSTRACT:

Background

A recent microarray study implicated arginase I (ARG1) and arginase II (ARG2) in mouse allergic asthma models and human asthma.

Objectives

To examine the association between genetic variation in ARG1 and ARG2 and childhood asthma and atopy risk.

Methods

We enrolled 433 case-parent triads, consisting of patients with asthma 4 to 17 years old and their biologic parents, from the allergy clinic of a public hospital in Mexico City between 1998 and 2003. Atopy to 24 aeroallergens was determined by skin prick tests. We genotyped 4 single nucleotide polymorphisms (SNPs) of ARG1 and 4 SNPs of ARG2 with minor allele frequencies higher than 10% by using the TaqMan assay (Roche Molecular Systems, Pleasanton, Calif).

Results

ARG1 SNPs and haplotypes were not ass

SUBMITTER: Li H 

PROVIDER: S-EPMC1450009 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature