Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice.

ABSTRACT: Disrupted-In-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that introduces a termination codon at exon 7, abolishes production of the full-length protein, and impairs working memory performance when transferred to the C57BL/6J genetic background. Our findings provide insights into how DISC1 variation contributes to schizophrenia susceptibility in humans and the behavioral divergence between 129S6/SvEv and C57BL/6J mouse strains and have implications for modeling psychiatric diseases in mice.

SUBMITTER: Koike H 

PROVIDER: S-EPMC1450143 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature