Classification of protein quaternary structure by functional domain composition.

ABSTRACT:

Background

The number and the arrangement of subunits that form a protein are referred to as quaternary structure. Quaternary structure is an important protein attribute that is closely related to its function. Proteins with quaternary structure are called oligomeric proteins. Oligomeric proteins are involved in various biological processes, such as metabolism, signal transduction, and chromosome replication. Thus, it is highly desirable to develop some computational methods to automatically classify the quaternary structure of proteins from their sequences.

Results

To explore this problem, we adopted an approach based on the functional domain composition of proteins. Every protein was represented by a vector calculated from the domains in the PFAM database. The nearest neig

SUBMITTER: Yu X 

PROVIDER: S-EPMC1450311 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature