Detection of genes for ordinal traits in nuclear families and a unified approach for association studies.

ABSTRACT: There is growing interest in genomewide association analysis using single-nucleotide polymorphisms (SNPs), because traditional linkage studies are not as powerful in identifying genes for common, complex diseases. Tests for linkage disequilibrium have been developed for binary and quantitative traits. However, since many human conditions and diseases are measured in an ordinal scale, methods need to be developed to investigate the association of genes and ordinal traits. Thus, in the current report we propose and derive a score test statistic that identifies genes that are associated with ordinal traits when gametic disequilibrium between a marker and trait loci exists. Through simulation, the performance of this new test is examined for both ordinal traits and quantitative traits. The pro

SUBMITTER: Zhang H 

PROVIDER: S-EPMC1456175 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature