High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing.

ABSTRACT: For decades, classical crossover studies and linkage disequilibrium (LD) analysis of genomic regions suggested that human meiotic crossovers may not be randomly distributed along chromosomes but are focused instead in "hot spots." Recent sperm typing studies provided data at very high resolution and accuracy that defined the physical limits of a number of hot spots. The data were also used to test whether patterns of LD can predict hot spot locations. These sperm typing studies focused on several small regions of the genome already known or suspected of containing a hot spot based on the presence of LD breakdown or previous experimental evidence of hot spot activity. Comparable data on target regions not specifically chosen using these two criteria is lacking but is needed to make an unbia

SUBMITTER: Tiemann-Boege I 

PROVIDER: S-EPMC1456319 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature