Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction.

ABSTRACT:

Background

Recent results from animal studies suggest that stem cells may be able to home to sites of myocardial injury to assist in tissue regeneration. However, the histological interpretation of postmortem tissue, on which many of these studies are based, has recently been widely debated.

Methods and results

With the use of the high sensitivity of a combined single-photon emission CT (SPECT)/CT scanner, the in vivo trafficking of allogeneic mesenchymal stem cells (MSCs) colabeled with a radiotracer and MR contrast agent to acute myocardial infarction was dynamically determined. Redistribution of the labeled MSCs after intravenous injection from initial localization in the lungs to nontarget organs such as the liver, kidney, and spleen was observed within 24 to 48 hours af

SUBMITTER: Kraitchman DL 

PROVIDER: S-EPMC1456731 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature