Multiple signatures of positive selection downstream of notch on the X chromosome in Drosophila melanogaster.

ABSTRACT: To identify genomic regions affected by the rapid fixation of beneficial mutations (selective sweeps), we performed a scan of microsatellite variability across the Notch locus region of Drosophila melanogaster. Nine microsatellites spanning 60 kb of the X chromosome were surveyed for variation in one African and three non-African populations of this species. The microsatellites identified an approximately 14-kb window for which we observed relatively low levels of variability and/or a skew in the frequency spectrum toward rare alleles, patterns predicted at regions linked to a selective sweep. DNA sequence polymorphism data were subsequently collected within this 14-kb region for three of the D. melanogaster populations. The sequence data strongly support the initial microsatellite finding

SUBMITTER: DuMont VB 

PROVIDER: S-EPMC1456778 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature