Likelihoods from summary statistics: recent divergence between species.

ABSTRACT: We describe an importance-sampling method for approximating likelihoods of population parameters based on multiple summary statistics. In this first application, we address the demographic history of closely related members of the Drosophila pseudoobscura group. We base the maximum-likelihood estimation of the time since speciation and the effective population sizes of the extant and ancestral populations on the pattern of nucleotide variation at DPS2002, a noncoding region tightly linked to a paracentric inversion that strongly contributes to reproductive isolation. Consideration of summary statistics rather than entire nucleotide sequences permits a compact description of the genealogy of the sample. We use importance sampling first to propose a genealogical and mutational history consis

SUBMITTER: Leman SC 

PROVIDER: S-EPMC1456855 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature