SimArray: a user-friendly and user-configurable microarray design tool.

ABSTRACT:

Background

Microarrays were first developed to assess gene expression but are now also used to map protein-binding sites and to assess allelic variation between individuals. Regardless of the intended application, efficient production and appropriate array design are key determinants of experimental success. Inefficient production can make larger-scale studies prohibitively expensive, whereas poor array design makes normalisation and data analysis problematic.

Results

We have developed a user-friendly tool, SimArray, which generates a randomised spot layout, computes a maximum meta-grid area, and estimates the print time, in response to user-specified design decisions. Selected parameters include: the number of probes to be printed; the microtitre plate format; the printing

SUBMITTER: Auburn RP 

PROVIDER: S-EPMC1456992 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature