Deletions in the Y-derived amelogenin gene fragment in the Indian population.

ABSTRACT:

Background

Rare failures in amelogenin-based gender typing of individuals have been observed globally. In this study, we report the deletion of a large fragment of the amelogenin gene in 10 individuals out of 4,257 male samples analyzed from 104 different endogamous populations of India.

Methods

Samples were analyzed using commercial genetic profiling kits. Those that exhibited failures in amelogenin-based gender identification were further analyzed with published as well as newly designed primers to ascertain the nature and extent of mutation.

Results

The failure rate among Indian males was 0.23 %. Though the exact size and nature of the deletion (single point mutations at a number of positions or a single large deletion) could not be determined in the present study,

SUBMITTER: Kashyap VK 

PROVIDER: S-EPMC1458324 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature