DNA motifs in human and mouse proximal promoters predict tissue-specific expression.

ABSTRACT: Comprehensive identification of cis-regulatory elements is necessary for accurately reconstructing gene regulatory networks. We studied proximal promoters of human and mouse genes with differential expression across 56 terminally differentiated tissues. Using in silico techniques to discover, evaluate, and model interactions among sequence elements, we systematically identified regulatory modules that distinguish elevated from inhibited expression in the corresponding transcripts. We used these putative regulatory modules to construct a single predictive model for each of the 56 tissues. These predictors distinguish tissue-specific elevated from inhibited expression with statistical significance in 80% of the tissues (45 of 56). The predictors also reveal synergy between cis-regulatory mod

SUBMITTER: Smith AD 

PROVIDER: S-EPMC1458868 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature