Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.

ABSTRACT: Much evidence from studies in humans and animals supports the hypothesis that alcohol addiction is a complex disease with both hereditary and environmental influences. Molecular determinants of excessive alcohol consumption are difficult to study in humans. However, several rodent models show a high or low degree of alcohol preference, which provides a unique opportunity to approach the molecular complexities underlying the genetic predisposition to drink alcohol. Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,

SUBMITTER: Mulligan MK 

PROVIDER: S-EPMC1458884 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature