Dynamic changes in subgraph preference profiles of crucial transcription factors.

ABSTRACT: Transcription factors with a large number of target genes--transcription hub(s), or THub(s)--are usually crucial components of the regulatory system of a cell, and the different patterns through which they transfer the transcriptional signal to downstream cascades are of great interest. By profiling normalized abundances (A(N)) of basic regulatory patterns of individual THubs in the yeast Saccharomyces cerevisiae transcriptional regulation network under five different cellular states and environmental conditions, we have investigated their preferences for different basic regulatory patterns. Subgraph-normalized abundances downstream of individual THubs often differ significantly from that of the network as a whole, and conversely, certain over-represented subgraphs are not preferred by any

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC1458966 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature