Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus.

ABSTRACT: In recent years we have studied the relationship between strain genotypes and patient phenotypes in group A Streptococcus (GAS), a model human bacterial pathogen that causes extensive morbidity and mortality worldwide. We have concentrated our efforts on serotype M3 organisms because these strains are common causes of pharyngeal and invasive infections, produce unusually severe invasive infections, and can exhibit epidemic behavior. Our studies have been hindered by the lack of genome-scale phylogenies of multiple GAS strains and whole-genome sequences of multiple serotype M3 strains recovered from individuals with defined clinical phenotypes. To remove some of these impediments, we sequenced to closure the genome of four additional GAS strains and conducted comparative genomic resequencin

SUBMITTER: Beres SB 

PROVIDER: S-EPMC1459018 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature