The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt.

ABSTRACT:

Background

Serotonergic neurotransmission has been implicated in suicidal behavior. Association between suicidal completers and a regulatory C(-1019)G polymorphism (rs6295) in the serotonin 1A receptor (HTR1A) gene was previously reported, whereas a following study showed no association in a sample of suicide attempters.

Methods

The involvement of the implicated G-allele of the 5-HTR1A C(-1019)G polymorphism (rs6295) was analyzed with the transmission disequilibrium test (TDT) in a sample of 272 suicide attempter families.

Results

No overtransmission of the G-allele was found in the entire sample of suicide attempters (p = 0.1460; n = 272 trios). However, a strong trend for overtransmission of the G-allele was observed in a sub-sample selected for a high level of prev

SUBMITTER: Wasserman D 

PROVIDER: S-EPMC1459178 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature