Breast tumor copy number aberration phenotypes and genomic instability.

ABSTRACT:

Background

Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mutated (e.g. those involved in mitosis, replication, repair, and telomeres) are rarely mutated in chromosomally unstable sporadic tumors, even though such mutations are associated with some heritable cancer prone syndromes.

Methods

We applied array comparative genomic hybridization (CGH) to the analysis of breast tumors. The variation in the levels of genomic instability amongst tumors prompted us to investigate whether alterations in processes/genes involved in maintenance and/or manipulation of the genome were associated with particular types of genomic inst

SUBMITTER: Fridlyand J 

PROVIDER: S-EPMC1459181 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature