Impact of CNS treatment on mood in adult survivors of childhood leukemia: a report from the Children's Cancer Group.

ABSTRACT:

Purpose

This study assessed the relationship between CNS treatment and psychologic mood using the Profile of Moods State (POMS), a standardized measure of affect, among a large sample of young adult survivors of childhood acute lymphoblastic leukemia (ALL; N = 555).

Patients and methods

Survivors of childhood ALL (ages 18 to 33 years at study entry) participated in a structured telephone interview eliciting demographic, health, and behavioral data and the POMS. Treatment data included total dose of CNS irradiation (CRT) and intrathecal methotrexate (MTX) obtained from medical records.

Results

Mood disturbance was reported by 24% of survivors. High-dose CRT and MTX predicted disturbance rates modestly and primarily in combination with education variables. Interactions

SUBMITTER: Glover DA 

PROVIDER: S-EPMC1459335 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature