The mushroom body defect gene product is an essential component of the meiosis II spindle apparatus in Drosophila oocytes.

ABSTRACT: In addition to their well-known effects on the development of the mushroom body, mud mutants are also female sterile. Here we show that, although the early steps of ovary development are grossly normal, a defect becomes apparent in meiosis II when the two component spindles fail to cohere and align properly. The products of meiosis are consequently mispositioned within the egg and, with or without fertilization, soon undergo asynchronous and spatially disorganized replication. In wild-type eggs, Mud is found associated with the central spindle pole body that lies between the two spindles of meiosis II. The mutant defect thus implies that Mud should be added to the short list of components that are required for the formation and/or stability of this structure. Mud protein is also normally f

SUBMITTER: Yu JX 

PROVIDER: S-EPMC1461445 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature