High frequency, synchronized bursting drives eye-specific segregation of retinogeniculate projections.

ABSTRACT: Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By comparing retinal spiking patterns in several mutant mice with differing levels of eye-specific segregation, we show that the presence of high-frequency bursts synchronized across neighboring retinal ganglion cells correlates with robust eye-specific segregation and that the presence of high levels of asynchronous spikes does not inhibit this segregation. These findings provide a possible resolution to previously described discrepancies regarding the role of retinal waves in ret

SUBMITTER: Torborg CL 

PROVIDER: S-EPMC1463890 | biostudies-literature | 2005 Jan

REPOSITORIES: biostudies-literature