Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine.

ABSTRACT:

Objective

To review the evidence for ethnic differences in susceptibility to adverse drug reactions (ADRs) to cardiovascular drugs.

Design

Systematic review and meta-analysis.

Data sources

We searched Medline and Embase to March 2005. Reference lists of identified articles were hand searched for further relevant articles.

Review methods

Studies were eligible for inclusion if they included at least two ethnic groups and one or more ADRs. We excluded case reports and case series.

Results

564 studies contained some description of ethnicity and an ADR, and 132 of them related to cardiovascular therapies. Twenty four studies provided data for ADRs for at least two ethnic groups and were therefore eligible for inclusion. In pooled analyses the relative risk of

SUBMITTER: McDowell SE 

PROVIDER: S-EPMC1463974 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature