Ontology highlight
ABSTRACT:
SUBMITTER: Jechlinger M
PROVIDER: S-EPMC1469776 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Jechlinger Martin M Sommer Andreas A Moriggl Richard R Seither Peter P Kraut Norbert N Capodiecci Paola P Donovan Michael M Cordon-Cardo Carlos C Beug Hartmut H Grünert Stefan S
The Journal of clinical investigation 20060601 6
Metastasis is the major cause of cancer morbidity, but strategies for direct interference with invasion processes are lacking. Dedifferentiated, late-stage tumor cells secrete multiple factors that represent attractive targets for therapeutic intervention. Here we show that metastatic potential of oncogenic mammary epithelial cells requires an autocrine PDGF/PDGFR loop, which is established as a consequence of TGF-beta-induced epithelial-mesenchymal transition (EMT), a faithful in vitro correlat ...[more]