Batai and Ngari viruses: M segment reassortment and association with severe febrile disease outbreaks in East Africa.

ABSTRACT: Ngari virus is an orthobunyavirus recently recognized as a reassortant between Bunyamwera virus and an as yet unidentified M segment donor. Analysis of M segment sequences of Batai and Ilesha viruses revealed 95% deduced amino acid identity between Batai virus and Ngari virus. These findings suggest Batai virus as the donor of Ngari virus M segment sequence. Analysis of Batai virus-related African isolates identified UgMP-6830, isolated from mosquitoes in Uganda, as an isolate of Batai virus. KV-141, isolated during a febrile disease outbreak in Sudan, was identified as another isolate of Ngari virus, emphasizing a role of this reassortant virus in severe human illness throughout East Africa.

SUBMITTER: Briese T 

PROVIDER: S-EPMC1472162 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature