Adaptive covariation between the coat and movement proteins of prunus necrotic ringspot virus.

ABSTRACT: The relative functional and/or structural importance of different amino acid sites in a protein can be assessed by evaluating the selective constraints to which they have been subjected during the course of evolution. Here we explore such constraints at the linear and three-dimensional levels for the movement protein (MP) and coat protein (CP) encoded by RNA 3 of prunus necrotic ringspot ilarvirus (PNRSV). By a maximum-parsimony approach, the nucleotide sequences from 46 isolates of PNRSV varying in symptomatology, host tree, and geographic origin have been analyzed and sites under different selective pressures have been identified in both proteins. We have also performed covariation analyses to explore whether changes in certain amino acid sites condition subsequent variation in other sit

SUBMITTER: Codoner FM 

PROVIDER: S-EPMC1472603 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature