Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes.

ABSTRACT: Most common genetic disorders have a complex inheritance and may result from variants in many genes, each contributing only weak effects to the disease. Pinpointing these disease genes within the myriad of susceptibility loci identified in linkage studies is difficult because these loci may contain hundreds of genes. However, in any disorder, most of the disease genes will be involved in only a few different molecular pathways. If we know something about the relationships between the genes, we can assess whether some genes (which may reside in different loci) functionally interact with each other, indicating a joint basis for the disease etiology. There are various repositories of information on pathway relationships. To consolidate this information, we developed a functional human gene ne

SUBMITTER: Franke L 

PROVIDER: S-EPMC1474084 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature