Familial osteoarthritis of the hip joint associated with acetabular dysplasia maps to chromosome 13q.

ABSTRACT: Genetic factors have been implicated in osteoarthritis (OA), particularly in OA of the hip joint (hip OA). Several instances of familial hip OA that show distinctive modes of inheritance but that differ from chondrodysplasia have been reported. Here, we report the characterization of a large Japanese family with an inherited disease of the hip that is indistinguishable from common hip OA, as evidenced by clinical symptoms and radiographs of the joint. This family contained eight patients in 4 generations. Affected individuals develop pain in the hip joint during adolescence, and the disease progresses to severe crippling before age 60 years. Patients generally are in good health, height is not reduced, and there is no extraskeletal involvement suggestive of chondrodysplasia. The skeletal c

SUBMITTER: Mabuchi A 

PROVIDER: S-EPMC1474113 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature