Trait components provide tools to dissect the genetic susceptibility of migraine.

ABSTRACT: The commonly used "end diagnosis" phenotype that is adopted in linkage and association studies of complex traits is likely to represent an oversimplified model of the genetic background of a disease. This is also likely to be the case for common types of migraine, for which no convincingly associated genetic variants have been reported. In headache disorders, most genetic studies have used end diagnoses of the International Headache Society (IHS) classification as phenotypes. Here, we introduce an alternative strategy; we use trait components--individual clinical symptoms of migraine--to determine affection status in genomewide linkage analyses of migraine-affected families. We identified linkage between several traits and markers on chromosome 4q24 (highest LOD score under locus heterogen

SUBMITTER: Anttila V 

PROVIDER: S-EPMC1474123 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature