Alternative promoter usage of the membrane glycoprotein CD36.

ABSTRACT:

Background

CD36 is a membrane glycoprotein involved in a variety of cellular processes such as lipid transport, immune regulation, hemostasis, adhesion, angiogenesis and atherosclerosis. It is expressed in many tissues and cell types, with a tissue specific expression pattern that is a result of a complex regulation for which the molecular mechanisms are not yet fully understood. There are several alternative mRNA isoforms described for the gene. We have investigated the expression patterns of five alternative first exons of the CD36 gene in several human tissues and cell types, to better understand the molecular details behind its regulation.

Results

We have identified one novel alternative first exon of the CD36 gene, and confirmed the expression of four previously known a

SUBMITTER: Andersen M 

PROVIDER: S-EPMC1475603 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature