Association between cigarette smoking, APC mutations and the risk of developing sporadic colorectal adenomas and carcinomas.

ABSTRACT:

Background

The association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenomatous polyposis coli (APC) gene has been reported to have a "gatekeeper" function in the colonic mucosa.

Methods

To evaluate the hypothesis that cigarette smoking is associated with adenoma and carcinoma development and further to investigate whether this association is due to mutations in the APC gene, we used a study population consisting of 133 cases (45 adenomas and 88 carcinomas) and 334 controls. All tumors were sequenced in the mutation cluster region (MCR) of the APC gene. Cases and controls were drawn from a homogeneous cohort of Norwegian origin.

SUBMITTER: Sarebo M 

PROVIDER: S-EPMC1475604 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature